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Antonella D'Amore

Post-doctoral Fellow

Research Interests

The cancer cell's genome is the end result of the accumulation of somatic mutations generated during a cell’s lifetime. In particular for gastrointestinal cancers, there are several exogenous and endogenous agents that can generate genome instability. While the carcinogenic effect of some food (alcohol, red meat) has been under a strong mediatic focus, the potential carcinogenic effect of specific bacterial members of the human microbiota is still underexplored. I am investigating bacterial toxins that cause host genomic instability and mutational processes that initiate cancer. Understanding the effect of bacterial toxins promises to have implications for cancer prevention and early treatment.

Background

I completed my PhD in 2020 at “Sapienza” University of Rome (Italy) where I studied the role of an endo-lysosomal sodium/calcium channel (Two Pore Channel 2-TPC2) in melanoma progression. During my PhD I spent 9 months at the Department of Pharmacology (University of Oxford) supported by a PhD Mobility Call for Young Researchers Fellowship.