The cancer cell's genome is the end result of the accumulation of somatic mutations generated during a cell’s lifetime. In particular for gastrointestinal cancers, there are several exogenous and endogenous agents that can generate genome instability. While the carcinogenic effect of some food (alcohol, red meat) has been under a strong mediatic focus, the potential carcinogenic effect of specific bacterial members of the human microbiota is still underexplored. I am investigating bacterial toxins that cause host genomic instability and mutational processes that initiate cancer. Understanding the effect of bacterial toxins promises to have implications for cancer prevention and early treatment.
I completed my PhD in 2020 at “Sapienza” University of Rome (Italy) where I studied the role of an endo-lysosomal sodium/calcium channel (Two Pore Channel 2-TPC2) in melanoma progression. During my PhD I spent 9 months at the Department of Pharmacology (University of Oxford) supported by a PhD Mobility Call for Young Researchers Fellowship.