Several DNA and RNA modifications have been proven to play an important role in cancer development. However, traditional methods to detect these modifications mainly rely on harsh chemical treatment, which is intrinsically unfriendly to low-input samples. Although antibody- or immunoprecipitation-based methods could also be used, they are not quantitative and could not provide base-resolution information. My current work is to develop new chemistry to label and detect the epigenetic modifications of DNA and RNA, with the goal of applying these tools to establish novel single-cell sequencing methods to study cancer heterogeneity.
I obtained my Bachelor’ degree in Chemistry from the College of Chemistry and Molecular Engineering at Peking University, where I focused on developing novel methods to detect low-abundance DNA mutations in circulating cell-free DNA.