Contact information
Research groups
Ines Kaltheuner
Post-doctoral Fellow
Research interests
I am a protein biochemist with a background in structural biology and am particularly interested in enzymes that control RNA polymerase II and the epigenome through post-translational modifications such as methylation, acetylation and phosphorylation. I am investigating their functional role in transcriptional regulation, but moreover, many of these enzymes are involved in oncogenesis and I aim to identify new chemical probes with potential therapeutic applications in cancer.
background
I completed my BSc in Biology at the University of Hamburg and my MSc and PhD (Dr.rer.nat.) at the University of Bonn, Germany, where I investigated structural and functional aspects of human kinases regulating RNA polymerase II. In 2024, I joined Yang Shi's lab as a Postdoctoral Researcher.
Recent publications
Discovery of an LSD1 PROTAC degrader.
Journal article
Hosseini A. et al, (2025), Proceedings of the National Academy of Sciences of the United States of America, 122
The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation.
Journal article
Schmitz M. et al, (2024), The Journal of biological chemistry, 300
Oncogenic CDK13 mutations impede nuclear RNA surveillance.
Journal article
Insco ML. et al, (2023), Science (New York, N.Y.), 380
