Senior Research Officer
I studied for a BSc in biochemistry at SiChuan University and did my MSc at Peking Union Medical College/Chinese Academy of Medical Science. After being awarded a bursarship from the Imperial Cancer Research Fund (ICRF, now Cancer Research UK), I did my PhD at University College London. I did a one year post-doc at the Biomedical Research Centre, University of Dundee, before joining Professor Xin Lu’s group at the Ludwig Institute for Cancer Research in 1993 as a scientific officer.
I provide colleagues in the group with technical support and this contribution is shown the several recent publications.
Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP.
Lu M, Breyssens H, Salter V, Zhong S, Hu Y, Baer C, Ratnayaka I, Sullivan A, Brown NR, Endicott J, Knapp S, Kessler BM, Middleton MR, Siebold C, Jones EY, Sviderskaya EV, Cebon J, John T, Caballero OL, Goding CR, Lu X. Cancer Cell. 2016 Nov 14;30(5):822-823. doi: 10.1016/j.ccell.2016.09.019.
iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death.
Notari M, Hu Y, Sutendra G, Dedeić Z, Lu M, Dupays L, Yavari A, Carr CA, Zhong S, Opel A, Tinker A, Clarke K, Watkins H, Ferguson DJ, Kelsell DP, de Noronha S, Sheppard MN, Hollinshead M, Mohun TJ, Lu X. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E973-81. doi: 10.1073/pnas.1408111112.
ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1.
Wang Y, Bu F, Royer C, Serres S, Larkin JR, Soto MS, Sibson NR, Salter V, Fritzsche F, Turnquist C, Koch S, Zak J, Zhong S, Wu G, Liang A, Olofsen PA, Moch H, Hancock DC, Downward J, Goldin RD, Zhao J, Tong X, Guo Y, Lu X. Nat Cell Biol. 2014 Nov;16(11):1092-104. doi: 10.1038/ncb3050.
ASPP2 links the apical lateral polarity complex to the regulation of YAP activity in epithelial cells.
Royer C, Koch S, Qin X, Zak J, Buti L, Dudziec E, Zhong S, Ratnayaka I, Srinivas S, Lu X. PLoS One. 2014 Oct 31;9(10):e111384. doi: 10.1371/journal.pone.0111384.