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Shreepriya Das
Post-doctoral Fellow
Research interests
TET-Assisted Pyridine-borane Sequencing (TAPS) is a recently developed novel sequencing method to measure epigenetic DNA modifications. TAPS does not involve bisulphite treatment, but instead uses a mild enzymatic reaction to oxidize methylated cytosine to carboxyl-cytosine, which is further converted to di-hydroxy-uracil in a reaction catalysed by pyridine-borane, which is read as thymine after PCR and sequencing. I am primarily interested in novel and efficient computational tools for processing TAPS data, including improved algorithmic schemes. These tools are expected to be of vital importance for analysing various cancer datasets.
Background
I grew up in Kolkata, India and went to the Indian Institute of Technology, Kharagpur for my undergraduate studies. I obtained my PhD from The University of Texas at Austin, USA. Subsequently I have held post-doctoral positions at Harvard Medical School and The University of Michigan at Ann Arbor.