Ludwig Cancer Research engages leading scientists and clinicians in an integrated effort to understand and confront the challenge of cancer. The Oxford Branch is based at the University of Oxford and benefits from excellent links with the global Ludwig and local Oxford research communities.
Findings from a study led by Colin Goding uncover an ancient mechanism that makes cancer cells invasive, explains melanoma’s resistance to therapy and opens the door to development of novel cancer therapies. Published in the current issue of the journal Genes & Development, the study illuminates the crucial role that punishing conditions within the tumour play in molding a subset of tumor cells into an invasive state.
Panagis Filippakopoulos and Takao Fujisawa have a new review article in Nature Reviews Molecular Cell Biology about a class of proteins - called bromodomain proteins - that are frequently dysregulated in cancer. Bromodomains are involved in protein-protein interactions and have important roles in the regulation of gene expression.
Functions of bromodomain-containing proteins and their roles in homeostasis and cancer. Nat Rev Mol Cell Biol. Article
Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin. Cell Rep, 17 (10), pp. 2724-2737. Article
MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated. Nat Commun, 7, pp. 13701. Article
MEF2 transcription factors are key regulators of sprouting angiogenesis. Genes Dev, 30 (20), pp. 2297-2309. Article
Cancer Genetics May Aid Diagnostics of Developmental Disorders. Hum Mutat, 37 (10), pp. 989. Article
Our researchers are investigating all stages of cancer, from the risk of disease through to new treatment opportunities. Many of the research groups are interested the causes and consequences of differences among cells within a tumour and variability among different tumours. Find out more about the Ludwig research groups.
Ludwig Seminars take place in the NDMRB (TDI) Basement Seminar Room. All University members welcome.
Dr Jan Rehwinkel: Nucleic acid sensing by innate immune receptors, 26/Jan/2017 11:00
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