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Ludwig Cancer Research engages leading scientists and clinicians in an integrated effort to understand and confront the challenge of cancer. The Oxford Branch is based at the University of Oxford and benefits from excellent links with the global Ludwig and local Oxford research communities.

News

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Ludwig study reveals why cancer cells spread within the body

Posted 17/01/2017

Findings from a study led by Colin Goding uncover an ancient mechanism that makes cancer cells invasive, explains melanoma’s resistance to therapy and opens the door to development of novel cancer therapies. Published in the current issue of the journal Genes & Development, the study illuminates the crucial role that punishing conditions within the tumour play in molding a subset of tumor cells into an invasive state.

Bromodomain proteins in cancer

Posted 06/01/2017

Panagis Filippakopoulos and Takao Fujisawa have a new review article in Nature Reviews Molecular Cell Biology about a class of proteins - called bromodomain proteins - that are frequently dysregulated in cancer. Bromodomains are involved in protein-protein interactions and have important roles in the regulation of gene expression.

Recent publications

Functions of bromodomain-containing proteins and their roles in homeostasis and cancer. Nat Rev Mol Cell Biol. Article

Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin. Cell Rep, 17 (10), pp. 2724-2737. Article

MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated. Nat Commun, 7, pp. 13701. Article

MEF2 transcription factors are key regulators of sprouting angiogenesis. Genes Dev, 30 (20), pp. 2297-2309. Article

Cancer Genetics May Aid Diagnostics of Developmental Disorders. Hum Mutat, 37 (10), pp. 989. Article

Research

Our researchers are investigating all stages of cancer, from the risk of disease through to new treatment opportunities. Many of the research groups are interested the causes and consequences of differences among cells within a tumour and variability among different tumours. Find out more about the Ludwig research groups.

Seminars

Ludwig Seminars take place in the NDMRB (TDI) Basement Seminar Room. All University members welcome.

Dr Jan Rehwinkel: Nucleic acid sensing by innate immune receptors, 26/Jan/2017 11:00

Browse the Ludwig Seminar Series

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