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Ludwig Cancer Research engages leading scientists and clinicians in an integrated effort to understand and confront the challenge of cancer. The Oxford Branch is based at the University of Oxford, UK and benefits from excellent links with the global Ludwig and local Oxford research communities. Ludwig Cancer Research Oxford recently celebrated its 10th Anniversary with a two-day Symposium held in September 2017, which was attended by members of the global Ludwig community, Ludwig Oxford branch and the Oxford cancer research community:

News

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A cell autonomous role for iASPP

Posted 23/01/2018

Zinaida Dedeic and colleagues from Xin Lu’s group at Ludwig Oxford have shown how iASPP – a regulator of p53 and p63 – leads to cardiac and skin defects, in a paper published in Cell Death and Differentiation. Mutation of iASPP is known to cause cardiocutaneous syndrome, including cardiac dysfunction and impaired wound healing, but it wasn’t known whether these changes were due to iASPP-mediated regulation in heart and skin cells or via a widespread inflammatory response. Specific deletion of iASPP in either heart or skin cells in this new study supports a cell autonomous role of iASPP in cardiocutaneous disorder.

Group Leader in Cancer Big Data

Posted 09/01/2018

Grade 9: £46,336 - £53,691 with a discretionary market supplement up to £64,000 p.a.

We are looking for a Group Leader with research interests in statistical and computational analysis, and integration of genome-scale data to build a research program relating to cancer biology. With mentorship from senior group leaders, you will develop an effective, productive research group, supervise postgraduate researchers and graduate students and collaborate with other members of the Big Data Institute, LICR and the wider Oxford community. Applications must be made online by 12 noon on 7th February 2018.

Recent publications

Macrophage Cytoplasmic Transfer in Melanoma Invasion. Dev Cell, 43 (5), pp. 543-544. Article

Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes. Nat Commun, 8 (1), pp. 1404. Article

Peptide splicing by the proteasome. J Biol Chem, 292 (51), pp. 21170-21179. Article

Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD). J Cell Sci, 130 (19), pp. 3322-3335. Article

Learning from the Proteasome How To Fine-Tune Cancer Immunotherapy. Trends Cancer, 3 (10), pp. 726-741. Article

Research

Our researchers are investigating all stages of cancer, from the risk of disease through to new treatment opportunities. Many of the research groups are interested the causes and consequences of differences among cells within a tumour and variability among different tumours. Find out more about the Ludwig research groups.

Seminars

Ludwig Seminars take place in the NDMRB (TDI) Basement Seminar Room. All University members welcome.

Dr Yinyin Yuang: Deciphering the tumour ecosystem, 29/Jan/2018 11:00

Browse the Ludwig Seminar Series

 

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