Ludwig Cancer Research engages leading scientists and clinicians in an integrated effort to understand and confront the challenge of cancer. The Oxford Branch is based at the University of Oxford, UK and benefits from excellent links with the global Ludwig and local Oxford research communities. Ludwig Cancer Research Oxford recently celebrated its 10th Anniversary with a two-day Symposium held in September 2017, which was attended by members of the global Ludwig community, Ludwig Oxford branch and the Oxford cancer research community:
AI @ Oxford on 27th March 2018 is a unique opportunity for industry to see the state-of-the-art in artificial intelligence and machine learning at Oxford University, and meet Oxford’s AI experts one-to-one. At Ludwig Oxford, Jens Rittscher’s and Xin Lu’s labs are researching the use of machine learning to automate clinical image analysis.
Zinaida Dedeic and colleagues from Xin Lu’s group at Ludwig Oxford have shown how iASPP – a regulator of p53 and p63 – leads to cardiac and skin defects, in a paper published in Cell Death and Differentiation. Mutation of iASPP is known to cause cardiocutaneous syndrome, including cardiac dysfunction and impaired wound healing, but it wasn’t known whether these changes were due to iASPP-mediated regulation in heart and skin cells or via a widespread inflammatory response. Specific deletion of iASPP in either heart or skin cells in this new study supports a cell autonomous role of iASPP in cardiocutaneous disorder.
World Cancer Day on 4th February is dedicated to raising awareness about cancer. The mandate includes the possibility of preventing cancer, advancing and improving access to care, changing perceptions about cancer and building the case for greater global investment in cancer control. Researchers at Ludwig Oxford are trying to understand the epidemiology and potential causes of cancer, as well as the basic science underpinning the unregulated cell growth that is the hallmark of the disease.
Erratum to "DNA Replication and associated repair pathways are involved in the mutagenesis of methylated cytosine"[DNA Repair, 62 (2018) 1-7]. DNA Repair (Amst). Article
Cell autonomous role of iASPP deficiency in causing cardiocutaneous disorders. Cell Death Differ, pp. 1-15. Article
Cell and molecular biology: a new section joins the fight against cancer. Br J Cancer, 118 (1), pp. 1-2. Article
Macrophage Cytoplasmic Transfer in Melanoma Invasion. Dev Cell, 43 (5), pp. 543-544. Article
DNA Replication and associated repair pathways are involved in the mutagenesis of methylated cytosine. DNA Repair (Amst), 62, pp. 1-7. Article
Our researchers are investigating all stages of cancer, from the risk of disease through to new treatment opportunities. Many of the research groups are interested the causes and consequences of differences among cells within a tumour and variability among different tumours. Find out more about the Ludwig research groups.
Ludwig Seminars take place in the NDMRB (TDI) Basement Seminar Room. All University members welcome.
Dr Bin-Zhi Qian: Macrophage heterogeneity in cancer metastasis and therapy resistance, 19/Mar/2018 10:00
Browse the Ludwig Seminar Series