no-js

Ludwig Cancer Research engages leading scientists and clinicians in an integrated effort to understand and confront the challenge of cancer. The Oxford Branch is based at the University of Oxford, UK and benefits from excellent links with the global Ludwig and local Oxford research communities. Ludwig Cancer Research Oxford celebrated its 10th Anniversary with a two-day Symposium held in September 2017, which was attended by members of the global Ludwig community, Ludwig Oxford branch and the Oxford cancer research community:

News

Xin & Ben 286x100

Single cell transcriptomics gives insights into Barrett’s oesophagus

Posted 15/10/2018

Barrett’s oesophagus is a condition associated with gastric reflux that increases the chance of developing oesophageal cancer by 30-fold. A key question is how Barrett’s oesophagus arises from normal gastrointestinal tissue. However, because there are several different types of cells within Barrett’s oesophagus, research into the cellular origins of this tissue is difficult. To overcome this challenge, Ludwig Oxford’s Richard Owen, Michael White and David Severson from Xin Lu’s and Benjamin Schuster-Böckler’s labs performed single cell RNA sequencing on patient biopsies from Barrett’s and normal oesophagus. Their results, published in Nature Communications, show that a cell population in Barrett’s oesophagus had most similarity to normal oesophageal submucosal gland cells. This finding has implications for the clinical diagnosis of Barrett’s oesophagus.

Senior Group Leader - Infection, Inflammation and Cancer Epigenetics

Posted 27/09/2018

Grade 10: £54,765 - £69,331 p.a.

Ludwig Cancer Research at the University of Oxford are seeking outstanding candidates for the position of Senior Group Leader (equivalent to Associate Professor) with research interests in the areas of  infection, inflammation and cancer epigenetics. The post benefits from significant core funding, state art of the facilities and opportunity for collaboration within a world class environment. Applications should be made online and must be received by 12.00 noon on Monday, 19 November 2018.

Recent publications

Mutational signature distribution varies with DNA replication timing and strand asymmetry. Genome Biol, 19 (1), pp. 129. Article

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export. Proc Natl Acad Sci U S A, 115 (37), pp. E8668-E8677. Article

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J, 37 (17), pp. e99372-e99372. Article

A TFEB nuclear export signal integrates amino acid supply and glucose availability. Nat Commun, 9 (1), pp. 2685. Article

PHD2 inactivation in Type I cells drives HIF-2α-dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies. J Physiol, 596 (18), pp. 4393-4412. Article

DNA Modifications: Naturally More Error Prone? Trends Genet, 34 (8), pp. 627-638. Article

Research

Our researchers are investigating all stages of cancer, from the risk of disease through to new treatment opportunities. Many of the research groups are interested the causes and consequences of differences among cells within a tumour and variability among different tumours. Find out more about the Ludwig research groups.

 

Seminars

Ludwig Seminars take place in the NDMRB (TDI) Basement Seminar Room. All University members welcome.

Dr Ze'ev Ronai: Inflammation and Microbiome in Cancer and Irritable Bowel Syndrome, 29/Oct/2018 11:00

Browse the Ludwig Seminar Series

 

 

 

abstract cell culture 940x100 160311n_0736