Ludwig Cancer Research engages leading scientists and clinicians in an integrated effort to understand and confront the challenge of cancer. The Oxford Branch is based at the University of Oxford, UK and benefits from excellent links with the global Ludwig and local Oxford research communities. Ludwig Cancer Research Oxford celebrated its 10th Anniversary with a two-day Symposium held in September 2017, which was attended by members of the global Ludwig community, Ludwig Oxford branch and the Oxford cancer research community:
The Journal of Cell Science has interviewed former Ludwig Oxford PhD student Norbert Volkmar as part of their “First Person” features. Norbert, a former graduate student from John Christianson’s lab, recently published his PhD research on the ER membrane protein complex in the journal. Norbert and other members of the Christianson group discovered that this complex is required for the correct synthesis of two important proteins that control the levels of cholesterol in the cell.
Cancer metastasis is the primary cause of cancer-related death but it is unclear why cancer cells migrate away from the original tumour site. In this review in Cell Metabolism, Ludwig Oxford’s Colin Goding and Custodia García-Jimenéz (Madrid) propose that invasive behaviour in cancer is caused either by nutrient or oxygen limitation within the tumour, or by signals from immune cells or therapy that hijack the cell’s starvation response to impose a pseudo-starvation state. By explaining how many apparently unrelated triggers for invasion converge on a single cell survival strategy, similar from bacteria to man, the authors identify a therapeutic vulnerability in invasive cancer cells.
On 13-14th December 2018, Ludwig Oxford had its Annual Retreat at Milton Hill House, near Abingdon. The two day event featured a varied programme of scientific talks, poster sessions, scientific communication exercises and public engagement activity brainstorming plus time to socialise with colleagues at the Institute Christmas lunch. ...
The ER membrane protein complex (EMC) promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. J Cell Sci, 132 (2). Article
IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis. Sci Rep, 8 (1), pp. 1520. Article
Apoptosis of tumor-infiltrating T lymphocytes: a new immune checkpoint mechanism. Cancer Immunol Immunother. Article
Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively. J Cell Sci, 131 (22), pp. jcs219782-jcs219782. Article
Single cell RNA-seq reveals profound transcriptional similarity between Barrett's oesophagus and oesophageal submucosal glands. Nat Commun, 9 (1), pp. 4261. Article
Our researchers are investigating all stages of cancer, from the risk of disease through to new treatment opportunities. Many of the research groups are interested the causes and consequences of differences among cells within a tumour and variability among different tumours. Find out more about the Ludwig research groups.
Ludwig Seminars take place in the NDMRB (TDI) Basement Seminar Room. All University members welcome.
Dr Gopinath Sutendra: Redox differences between the Heart and Tumour could provide a Selective Therapeutic Approach for Chemotherapy-Induced Cardiotoxicity, 05/Feb/2019 11:00
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