Ludwig Cancer Research engages leading scientists and clinicians in an integrated effort to understand and confront the challenge of cancer. The Oxford Branch is based at the University of Oxford, UK and benefits from excellent links with the global Ludwig and local Oxford research communities. Ludwig Cancer Research Oxford celebrated its 10th Anniversary with a two-day Symposium held in September 2017, which was attended by members of the global Ludwig community, Ludwig Oxford branch and the Oxford cancer research community:
Hypoxia-inducible factors (HIFs) are key factors in coordinating cellular responses to low oxygen levels (hypoxia) such as those frequently found in tumours. Factor inhibiting HIF (FIH) represses HIF when oxygen levels are normal. This study aimed to understand more about the regulation of HIF by FIH, in particular the effect of FIH location within the cell. Using fluorescence microscopy, Yihua Wang from Ludwig Oxford’s Xin Lu’s and Peter Ratcliffe’s labs studied the dynamics of FIH cellular localisation after hypoxia. Their results, published in The Journal of Cell Science, show that FIH accumulates in the nucleus for a short time soon after hypoxia treatment and that nuclear import and export are controlled by HIF1α and exportin1 respectively.
Registration is now open for the EMBO workshop on Pathogen immunity and signalling to be held at Keble College, Oxford, UK from 1st-5th April 2019. The meeting, co-organised by Ludwig Oxford researcher Mads Gyrd-Hansen, will focus on the immune response to infectious micro-organisms including pattern-recognition receptors, ubiquitin signalling and cytokines. Abstract submission deadline is 8th December.
The Ludwig Institute for Cancer Research and the Oxford Big Data Institute are seeking to recruit a Senior Group Leader (equivalent to Associate Professor) with research interests in the statistical and computational analysis and integration of genome-scale data with deep patient phenotyping. The postholder will have primary responsibility for the development, management and strategic direction of a significant research group.
The contract is for 5 years in the first instance as a tenure track position. Please apply via the University of Oxford online recruitment website by 12.00 noon on Friday 4th January 2019.
IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis. Sci Rep, 8 (1), pp. 1520. Article
Apoptosis of tumor-infiltrating T lymphocytes: a new immune checkpoint mechanism. Cancer Immunol Immunother. Article
Nuclear entry and export of FIH are mediated by HIF1α and exportin1 respectively. J Cell Sci. Article
Single cell RNA-seq reveals profound transcriptional similarity between Barrett's oesophagus and oesophageal submucosal glands. Nat Commun, 9 (1), pp. 4261. Article
Our researchers are investigating all stages of cancer, from the risk of disease through to new treatment opportunities. Many of the research groups are interested the causes and consequences of differences among cells within a tumour and variability among different tumours. Find out more about the Ludwig research groups.
Ludwig Seminars take place in the NDMRB (TDI) Basement Seminar Room. All University members welcome.
Professor Charles Bangham: Understanding the immune response to persistent human T-cell leukaemia virus (HTLV-I) infections (exact title tbc), 17/Jan/2019 11:00
Browse the Ludwig Seminar Series