Sinan Xiong

Research interests

The cellular secretome plays a critical role in mediating intercellular communication. My research focuses on understanding how epigenetic profiles of melanoma cells and neighbouring cells are altered within the tumour microenvironment. This work employs a combination of in vitro cell culture, model organisms, and multi-omics approaches, which aims to provide insights into the paracrine mechanisms underlying the epigenetic reprogramming of tumour microenvironmental cells during melanoma development and progression.

background

I completed my PhD study at the School of Medicine, National University of Singapore, where I focused on investigating epigenetic mechanisms and chromatin interactions in multiple myeloma, a type of blood cancer characterised by abnormal proliferation of plasma cells. My research revealed the acquisition of super-enhancers in multiple myeloma and identified novel oncogenes driven by long-range chromatin interactions, which may serve as potential therapeutic targets.