Adult hematopoietic stem cells lacking Hif-1α self-renew normally
Vukovic M., Sepulveda C., Subramani C., Guitart AV., Mohr J., Allen L., Panagopoulou TI., Paris J., Lawson H., Villacreces A., Armesilla-Diaz A., Gezer D., Holyoake TL., Ratcliffe PJ., Kranc KR.
Key Points Hif-1α is dispensable for cell-autonomous HSC survival. HSCs do not require intrinsic Hif-1α to respond to hematopoietic injury.