Luis Bermudez-Guzman

Research interests

I am interested in mutations: why they arise, how they occur, and how they alter DNA, protein structure, and cellular function. More specifically, I aim to understand why some mutations become cancer drivers while others remain passengers. My current work in the Kriaucionis Lab investigates how non-canonical nucleotides can become mutagenic and, ultimately, contribute to carcinogenesis.

Background

I completed my PhD at the University of Cambridge, based at the Cancer Research UK Cambridge Institute, where I worked on the molecular evolution of tyrosine kinases and the evolution of resistance to kinase inhibitors in patients. Before that, I completed undergraduate and postgraduate studies in biology and human genetics at the University of Costa Rica, and in bioinformatics and computational biology at the University of Chile, focusing on cancer biology and genotype-phenotype relationships in disease-associated mutations.