Senior Laboratory Manager
I’m the senior laboratory manager for the Ludwig Institute for Cancer Research. I provide operational management for the laboratories, ensuring as smooth and seamless a research environment as possible for the research staff and students. I also have responsibilities for procurement (consumables and service contracts) for the Institute and run tenders as appropriate for capital purchases. I am also the Departmental Safety Officer, Biological Safety Officer and Senior Radiation Protection Supervisor, key safety roles for ensuring that we operate in a safe manner and with due consideration for the environment. I provide advice for general laboratory practices and techniques. I maintain a keen interest in protein purification and method development, mentoring and advising members of the Ludwig on best practise and methodologies in chromatography.
Prior to joining the LICR, I worked for the Structural Genomics Consortium at the University of Oxford for 10 years as their laboratory manager, and before that as a post-doctoral researcher/laboratory engineer in Prof. Udo Oppermann’s group. Before that I worked for Oxford Glycosciences (one of the University of Oxford’s first spin-out companies) for 10 years, holding a variety of production and research roles culminating as a Research Scientist for an Antibody Therapeutics Group. I earned a DPhil from the Nuffield Department of Clinical Medicine in the SGC, with early research on the biochemistry and structural biology of histone demethylases. I hold a Higher National Diploma in Applied Biology (Biotechnology) from the University of the West of England and a NEBOSH National General Certificate in Occupational Health and Safety.
I provide advice and support as required to other NDM units on campus, mentoring laboratory managers. I have formed an informal campus working group of all the major laboratory managers and safety officers, where we can meet and share information.
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor
England KS. et al, (2014), Med. Chem. Commun., 5, 1879 - 1886
Ribosomal oxygenases are structurally conserved from prokaryotes to humans
Chowdhury R. et al, (2014), Nature, 510, 422 - 426
5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
Hopkinson RJ. et al, (2013), Chemical Science, 4, 3110 - 3110
Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases
Rose NR. et al, (2012), Journal of Medicinal Chemistry, 55, 6639 - 6643
Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases
Woon ECY. et al, (2012), Angewandte Chemie International Edition, 51, 1631 - 1634